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CAN CALIFORNIA AFFORD TO RENEW OUR STEM CELL
PROGRAM?

By Don C. Reed

On November 3rd, California voters will head to the polls and
make a potentially life-changing decision:

Can we afford to continue advancing life-saving and
life-changing medical research by dedicating $5.5 billion
dollars — to renew funding for our stem cell medical research
and treatment institute? (1)

In 2004, voters said “YES!” to Proposition 71, the
California Stem Cells for Research and Cures Act. By an almost 60%
favorable vote (59.05%), they created the California Institute for
Regenerative Medicine (CIRM). (2)

The results? A quiet triumph.

In addition to saving the lives of 50 children who had the
previously fatal autoimmune disorder known as Severe Combined
Immuno-deficiency (SCID, also referred to as “Bubble Babyâ€
disease) — funding from the 2004 proposition brought
treatments and cures which restored upper body function to
paralytics, developed two FDA-approved treatments for fatal blood
cancers, and provided a measurable return of vision to a blind
woman — who had never seen her twin children before. (3)

These successes are examples of the medical advancements from
more than 80 FDA-approved clinical trials — on cancer,
diabetes, stroke, Parkinson’s, and more — as a result of
CIRM funding. (4)

However, if California voters decided not to continue
California’s stem cell research program, many of these clinical
trials will be canceled, delayed, or stalled in the process. Before
that decision is made, let’s consider the real cost involved.

Last year, America spent nearly three TRILLION dollars on
chronic disease — ($2.976 trillion). (5)

How much is that? Three trillion dollar bills (in singles, laid
end to end) would make a money chain long enough to reach the moon.
(6)

In more practical terms, three trillion dollars is almost as
much as America’s federal income tax for individuals ($1.7
trillion) — and Social Security and Medicare taxes ($1.2
trillion) — totaling $2.9 trillion. (7)

Illness healed is money saved, in the best of all possible
ways.

When parents are told: “that disease which threatened your
child’s life? It is now gone, eradicatedâ€, that brings not only
joy, but tremendous financial relief as well.

Example: balance the complete cost of renewing the program, $5.5
billion — against just one year’s expense of a chronic
disease, diabetes.

According to the American Diabetes Association (ADA), diabetes
last year cost America $327 billion dollars. (8)

$5 billion for the program, $327 billion for one disease. Which
is more affordable?

CIRM has helped support a number of breakthroughs in fighting
both Type I & II diabetes: one possible therapy is a diabetes
“pacemakerâ€. Placed under the skin, it is designed to
contribute stem cell-derived insulin as needed, almost like a new
pancreas. (9)

What diabetic would not want to just forget the time-consuming
and painful pinpricks, or wearing insulin pumps , and being
endlessly cautious about every mouthful of food, struggling to
avoid the danger of improper blood sugar levels?

Here are some annual costs of four other diseases:

Cancer — $173 billion. (10)

Obesity — $147 billion (11)

Arthritis — $140 billion — (12)

Alzheimer’s disease — $159 billion — (13)

Compared to such annual costs, (repeated every year!) the
one-time expense of the program is couch change.

Did you know that medical emergency is the number one cause of
bankruptcy? As President Barack Obama said in his inaugural
address:

“…the crushing cost of healthcare…now causes a bankruptcy
in America every 30 seconds. By the end of this year, it could
cause 1.5 million Americans to lose their homes.†(14)

Even so, can we afford to maintain and renew the California stem
cell program?

Let’s look deeper.

The costs of repaying the bond sales (which funds the research)
are scheduled to be exactly nothing for the first five years.
I repeat, no cost to the state until
2026
. This was done for reasons of fairness, allowing time
for cures to develop. As clinical trials advance, the list of
breakthrough discoveries and treatments it delivers will doubtless
continue to grow; therefore, less payments in the beginning, when
benefits are just starting to become available.

As an added advantage, the state of California will benefit
greatly from the economic stimulus, desperately
needed during these challenging economic times — and without
taking away from the state’s ability to fund other critical
programs, addressing issues like education, housing, maintaining
emergency services, and COVID-19.

Why won’t funding CIRM jeopardize California’s other
spending needs?

On the contrary, funding CIRM provides more funding through
additional revenues from the stimulus effect it will
have — also, the total amount which can be spent by CIRM is
limited to less than 0.5% (one half of one per cent) of the 2019
bond capacity of California, leaving 99.5% of the bond capacity for
other needs.

In fact, the program is revenue positive for the first 8–9
years. That means that until the year 2029, more state revenues
will be generated by CIRM than the amount to fund this critical
program! These figures also do not include the amount the state
could be saving yearly from new treatments and cures created by
this research. The state will actually have more money to address
other important issues, by funding lifesaving medical research and
therapy development.

And now for something truly amazing. The California stem cell
program has already brought in more money to the state than it
actually cost.

How is that possible?

Look back in time for a prime example: a California law named
after my paralyzed son: the Roman Reed Spinal Cord Injury Research
Act of 1999. When California first started this program, it was
small, just $1.5 million a year for ten years, totaling $15
million. (15)

But when a scientist succeeds, it is much easier to get more
grant money. The RR Act spent $15 million in California
money — but the scientists did well and their work attracted
$87 million in add-ons and matching grants — whereby a $15
million program grew to roughly $102 million.

To chart CIRM’S financial effects, a study was done by Dan Wei
and Adam Rose of the University of Southern California (USC)’s
Schaeffer Center for Health Policy and Economics. (16)

In the measured years of 2004–2018, the study found numerous
benefits for both California and the nation. (The first three years
of CIRM’s existence, from 2004 to 2007, were blocked by
ideological lawsuits, frivolous litigation; although all these were
defeated, they delayed CIRM, which was not fully open until
2007.)

For California, from 2004 to 2018, an economic stimulus of $10.7
billion is estimated from “gross output†or sales revenue:
“the income received by a company from its sales of goods or the
provision of services.†Essentially, more sales revenue equals
increased market / economic activity. (17)

Additionally, more income from taxes ($641.3 million) was
brought in from the new biomed businesses and the scientists’
grants. Jobs? More than 50,000 (56,549) new Full Time Equivalent
(FTE) jobs came on line because of CIRM. These were good jobs,
paying well and in many areas, from construction to lab
technician.

And for the rest of America? The USC report details how
California’s stem cell program benefits not only California, but
the nation as well. In economic stimulus, $4.7 billion; in federal
tax revenues, $208.6 million — and 25,816 new FTE jobs.

With the funding originally entrusted to it, the California
Institute for Regenerative Medicine has performed well. It is an
exceptional and respected organization, which has earned the right
for voters to renew its funding, so it may continue to provide
treatments and cures, for the millions of Californians who need
them.

CIRM is a shining sword. We dare not let it lie and rust. We
must pick it up, and fight spinal cord injury, cancer, diabetes,
stroke, and every other chronic disease that citizens in this state
and country deal with daily.

CIRM has even funded several promising research projects to
fight COVID19 and other infectious diseases.

Can California afford to continue this terrific stimulus
program?

We can’t afford NOT to renew the California Institute for
Regenerative Medicine.

Look for it on your California ballot, and vote YES!

And if you live out of the state? Be sure and tell your
California friends about CIRM and the initiative to renew its
funding! We need everyone’s support.

Don C. Reed has written three books about the California stem
cell program, most recently “REVOLUTIONARY THERAPIES: How the
California Stem Cell Program Saved Lives, Eased Suffering, and
Changed the Face of Medicine Foreverâ€, from World Scientific,
Inc.. Available from the publisher, Amazon, or ask for it at your
local library, when it opens up again.

1.
https://www.lbbusinessjournal.com/should-california-invest-another-5-5-billion-into-stem-cell-research/

2.
https://en.wikipedia.org/wiki/2004_California_Proposition_71#Results_of_vote

3. https://blog.cirm.ca.gov/tag/bubble-baby-disease/page/2/

4. https://www.cirm.ca.gov/patients/power-stem-cells

5. — https://www.cdc.gov/chronicdisease/about/costs/index.htm

6. https://tinyurl.com/yahp4lor

7. — https://www.stlouisfed.org/open-vault/2019/november/where-federal-revenue-comes-from-how-spent

8. — https://www.diabetes.org/resources/statistics/cost-diabetes

9.
https://www.cirm.ca.gov/clinical-trial/clinical-trial-directly-vascularized-islet-cell-replacement-therapy-high-risk-type-0

10. — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107566/

11. — https://www.reuters.com/article/us-obesity-cost/obesity-costs-us-health-system-147-billion-study-idUSTRE56Q36020090727

12. https://www.cdc.gov/arthritis/data_statistics/cost.htm

13. https://www.rand.org/news/press/2013/04/03.html

14. https://www.nytimes.com/2009/03/05/us/politics/05obama-text.html

15. http://www.reeve.uci.edu/news-01-2019.html

16.
https://blog.cirm.ca.gov/2019/10/09/new-report-says-cirm-produces-big-economic-boost-for-california/

17.
Sales Revenue – Definition, Overview, and Examples

By Don C. Reed

On November 3rd, California voters will head to the polls and
make a potentially life-changing decision:

Can we afford to continue advancing life-saving and
life-changing medical research by dedicating $5.5 billion
dollars — to renew funding for our stem cell medical research
and treatment institute? (1)

In 2004, voters said “YES!” to Proposition 71, the
California Stem Cells for Research and Cures Act. By an almost 60%
favorable vote (59.05%), they created the California Institute for
Regenerative Medicine (CIRM). (2)

The results? A quiet triumph.

In addition to saving the lives of 50 children who had the
previously fatal autoimmune disorder known as Severe Combined
Immuno-deficiency (SCID, also referred to as “Bubble Babyâ€
disease) — funding from the 2004 proposition brought
treatments and cures which restored upper body function to
paralytics, developed two FDA-approved treatments for fatal blood
cancers, and provided a measurable return of vision to a blind
woman — who had never seen her twin children before. (3)

These successes are examples of the medical advancements from
more than 80 FDA-approved clinical trials — on cancer,
diabetes, stroke, Parkinson’s, and more — as a result of
CIRM funding. (4)

However, if California voters decided not to continue
California’s stem cell research program, many of these clinical
trials will be canceled, delayed, or stalled in the process. Before
that decision is made, let’s consider the real cost involved.

Last year, America spent nearly three TRILLION dollars on
chronic disease — ($2.976 trillion). (5)

How much is that? Three trillion dollar bills (in singles, laid
end to end) would make a money chain long enough to reach the moon.
(6)

In more practical terms, three trillion dollars is almost as
much as America’s federal income tax for individuals ($1.7
trillion) — and Social Security and Medicare taxes ($1.2
trillion) — totaling $2.9 trillion. (7)

Illness healed is money saved, in the best of all possible
ways.

When parents are told: “that disease which threatened your
child’s life? It is now gone, eradicatedâ€, that brings not only
joy, but tremendous financial relief as well.

Example: balance the complete cost of renewing the program, $5.5
billion — against just one year’s expense of a chronic
disease, diabetes.

According to the American Diabetes Association (ADA), diabetes
last year cost America $327 billion dollars. (8)

$5 billion for the program, $327 billion for one disease. Which
is more affordable?

CIRM has helped support a number of breakthroughs in fighting
both Type I & II diabetes: one possible therapy is a diabetes
“pacemakerâ€. Placed under the skin, it is designed to
contribute stem cell-derived insulin as needed, almost like a new
pancreas. (9)

What diabetic would not want to just forget the time-consuming
and painful pinpricks, or wearing insulin pumps , and being
endlessly cautious about every mouthful of food, struggling to
avoid the danger of improper blood sugar levels?

Here are some annual costs of four other diseases:

Cancer — $173 billion. (10)

Obesity — $147 billion (11)

Arthritis — $140 billion — (12)

Alzheimer’s disease — $159 billion — (13)

Compared to such annual costs, (repeated every year!) the
one-time expense of the program is couch change.

Did you know that medical emergency is the number one cause of
bankruptcy? As President Barack Obama said in his inaugural
address:

“…the crushing cost of healthcare…now causes a bankruptcy
in America every 30 seconds. By the end of this year, it could
cause 1.5 million Americans to lose their homes.†(14)

Even so, can we afford to maintain and renew the California stem
cell program?

Let’s look deeper.

The costs of repaying the bond sales (which funds the research)
are scheduled to be exactly nothing for the first five years.
I repeat, no cost to the state until
2026
. This was done for reasons of fairness, allowing time
for cures to develop. As clinical trials advance, the list of
breakthrough discoveries and treatments it delivers will doubtless
continue to grow; therefore, less payments in the beginning, when
benefits are just starting to become available.

As an added advantage, the state of California will benefit
greatly from the economic stimulus, desperately
needed during these challenging economic times — and without
taking away from the state’s ability to fund other critical
programs, addressing issues like education, housing, maintaining
emergency services, and COVID-19.

Why won’t funding CIRM jeopardize California’s other
spending needs?

On the contrary, funding CIRM provides more funding through
additional revenues from the stimulus effect it will
have — also, the total amount which can be spent by CIRM is
limited to less than 0.5% (one half of one per cent) of the 2019
bond capacity of California, leaving 99.5% of the bond capacity for
other needs.

In fact, the program is revenue positive for the first 8–9
years. That means that until the year 2029, more state revenues
will be generated by CIRM than the amount to fund this critical
program! These figures also do not include the amount the state
could be saving yearly from new treatments and cures created by
this research. The state will actually have more money to address
other important issues, by funding lifesaving medical research and
therapy development.

And now for something truly amazing. The California stem cell
program has already brought in more money to the state than it
actually cost.

How is that possible?

Look back in time for a prime example: a California law named
after my paralyzed son: the Roman Reed Spinal Cord Injury Research
Act of 1999. When California first started this program, it was
small, just $1.5 million a year for ten years, totaling $15
million. (15)

But when a scientist succeeds, it is much easier to get more
grant money. The RR Act spent $15 million in California
money — but the scientists did well and their work attracted
$87 million in add-ons and matching grants — whereby a $15
million program grew to roughly $102 million.

To chart CIRM’S financial effects, a study was done by Dan Wei
and Adam Rose of the University of Southern California (USC)’s
Schaeffer Center for Health Policy and Economics. (16)

In the measured years of 2004–2018, the study found numerous
benefits for both California and the nation. (The first three years
of CIRM’s existence, from 2004 to 2007, were blocked by
ideological lawsuits, frivolous litigation; although all these were
defeated, they delayed CIRM, which was not fully open until
2007.)

For California, from 2004 to 2018, an economic stimulus of $10.7
billion is estimated from “gross output†or sales revenue:
“the income received by a company from its sales of goods or the
provision of services.†Essentially, more sales revenue equals
increased market / economic activity. (17)

Additionally, more income from taxes ($641.3 million) was
brought in from the new biomed businesses and the scientists’
grants. Jobs? More than 50,000 (56,549) new Full Time Equivalent
(FTE) jobs came on line because of CIRM. These were good jobs,
paying well and in many areas, from construction to lab
technician.

And for the rest of America? The USC report details how
California’s stem cell program benefits not only California, but
the nation as well. In economic stimulus, $4.7 billion; in federal
tax revenues, $208.6 million — and 25,816 new FTE jobs.

With the funding originally entrusted to it, the California
Institute for Regenerative Medicine has performed well. It is an
exceptional and respected organization, which has earned the right
for voters to renew its funding, so it may continue to provide
treatments and cures, for the millions of Californians who need
them.

CIRM is a shining sword. We dare not let it lie and rust. We
must pick it up, and fight spinal cord injury, cancer, diabetes,
stroke, and every other chronic disease that citizens in this state
and country deal with daily.

CIRM has even funded several promising research projects to
fight COVID19 and other infectious diseases.

Can California afford to continue this terrific stimulus
program?

We can’t afford NOT to renew the California Institute for
Regenerative Medicine.

Look for it on your California ballot, and vote YES!

And if you live out of the state? Be sure and tell your
California friends about CIRM and the initiative to renew its
funding! We need everyone’s support.

Don C. Reed has written three books about the California stem
cell program, most recently “REVOLUTIONARY THERAPIES: How the
California Stem Cell Program Saved Lives, Eased Suffering, and
Changed the Face of Medicine Foreverâ€, from World Scientific,
Inc.. Available from the publisher, Amazon, or ask for it at your
local library, when it opens up again.

1.
https://www.lbbusinessjournal.com/should-california-invest-another-5-5-billion-into-stem-cell-research/

2.
https://en.wikipedia.org/wiki/2004_California_Proposition_71#Results_of_vote

3. https://blog.cirm.ca.gov/tag/bubble-baby-disease/page/2/

4. https://www.cirm.ca.gov/patients/power-stem-cells

5. — https://www.cdc.gov/chronicdisease/about/costs/index.htm

6. https://tinyurl.com/yahp4lor

7. — https://www.stlouisfed.org/open-vault/2019/november/where-federal-revenue-comes-from-how-spent

8. — https://www.diabetes.org/resources/statistics/cost-diabetes

9.
https://www.cirm.ca.gov/clinical-trial/clinical-trial-directly-vascularized-islet-cell-replacement-therapy-high-risk-type-0

10. — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107566/

11. — https://www.reuters.com/article/us-obesity-cost/obesity-costs-us-health-system-147-billion-study-idUSTRE56Q36020090727

12. https://www.cdc.gov/arthritis/data_statistics/cost.htm

13. https://www.rand.org/news/press/2013/04/03.html

14. https://www.nytimes.com/2009/03/05/us/politics/05obama-text.html

15. http://www.reeve.uci.edu/news-01-2019.html

16.
https://blog.cirm.ca.gov/2019/10/09/new-report-says-cirm-produces-big-economic-boost-for-california/

17.
Sales Revenue – Definition, Overview, and Examples

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