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The Source of Exosomes Matters

Many clinical studies have shown the safety and benefit of

exosomes
. As a result, numerous companies have been bringing
exosome products to market. However, not all exosomes are the same.
The cell type from which the exosomes are collected makes an
enormous difference in safety and results.

Scientists have recently drawn attention to the fact that

cell type matters
when it comes to exosomes. Virtually every
cell in the human body releases small packets of substances called
exosomes. The number of exosomes and the substances inside exosomes
can vary considerably, depending on the type of cell. Exosomes
derived from stem cells and stromal cells have received the most
research attention. That is because
exosomes
from stem cells contain most of the substances that
provide a benefit to patients from stem cells. In other words, if
you receive treatment of exosomes from stem cells, you are
basically getting additional benefits from the exosomes that you
would have gotten from just the stem cells themselves. However, the
source of the stem cell exosomes matter.

Most of the research done in this area revolves around two types
of stem cells: Exosomes taken from bone marrow mesenchymal stem
cells and exosomes taken from placental mesenchymal stem cells.
Bone marrow stem cells seem to have two major advantages over the
placenta-derived stem cells. The first is that bone marrow stem
cells have a stronger ability to modulate the immune system. The
second is that bone marrow stem cells have immune privilege, which
means they can avoid the body’s immune system. Specifically,
placenta stem cell exosomes contain higher levels of PDL1 and
HLA-G, which can make them more likely to provoke a negative immune
response.

Surprisingly but reasonably, there have been of 63,000
scientific articles published on the safety and efficacy of bone
marrow stem cells, but only about 1,200 on placenta stem cells.

Talk to your stem cell and exosome provider about your choices
of exosomes, and make sure to ask from what cell type the exosomes
are derived.

Reference: Hicok, Kevin & Vangsness, Thomas & Dordevic,
Maxwell. (2020). Exosome Origins: Why the Cell Source Matters. 4.
1-4.

The post The
Source of Exosomes Matters
appeared first on Stemedix.

Many clinical studies have shown the safety and benefit of

exosomes
. As a result, numerous companies have been bringing
exosome products to market. However, not all exosomes are the same.
The cell type from which the exosomes are collected makes an
enormous difference in safety and results.

Scientists have recently drawn attention to the fact that

cell type matters
when it comes to exosomes. Virtually every
cell in the human body releases small packets of substances called
exosomes. The number of exosomes and the substances inside exosomes
can vary considerably, depending on the type of cell. Exosomes
derived from stem cells and stromal cells have received the most
research attention. That is because
exosomes
from stem cells contain most of the substances that
provide a benefit to patients from stem cells. In other words, if
you receive treatment of exosomes from stem cells, you are
basically getting additional benefits from the exosomes that you
would have gotten from just the stem cells themselves. However, the
source of the stem cell exosomes matter.

Most of the research done in this area revolves around two types
of stem cells: Exosomes taken from bone marrow mesenchymal stem
cells and exosomes taken from placental mesenchymal stem cells.
Bone marrow stem cells seem to have two major advantages over the
placenta-derived stem cells. The first is that bone marrow stem
cells have a stronger ability to modulate the immune system. The
second is that bone marrow stem cells have immune privilege, which
means they can avoid the body’s immune system. Specifically,
placenta stem cell exosomes contain higher levels of PDL1 and
HLA-G, which can make them more likely to provoke a negative immune
response.

Surprisingly but reasonably, there have been of 63,000
scientific articles published on the safety and efficacy of bone
marrow stem cells, but only about 1,200 on placenta stem cells.

Talk to your stem cell and exosome provider about your choices
of exosomes, and make sure to ask from what cell type the exosomes
are derived.

Reference: Hicok, Kevin & Vangsness, Thomas & Dordevic,
Maxwell. (2020). Exosome Origins: Why the Cell Source Matters. 4.
1-4.

The post The
Source of Exosomes Matters
appeared first on Stemedix.

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