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Damaged muscles don’t just die, they regenerate
themselves
Researchers building a model of muscle damage in a cultured system
found that components leaking from broken muscle fibers activate
”satellite cells,” which are muscle stem cells. While attempting
to identify the activating proteins, they found that metabolic
enzymes, such as GAPDH, rapidly activated quiescent satellite cells
and accelerated muscle injury regeneration. This is a highly
rational and efficient regeneration mechanism, in which the damaged
muscle itself activates satellite cells for regeneration.
Researchers building a model of muscle damage in a cultured system
found that components leaking from broken muscle fibers activate
”satellite cells,” which are muscle stem cells. While attempting
to identify the activating proteins, they found that metabolic
enzymes, such as GAPDH, rapidly activated quiescent satellite cells
and accelerated muscle injury regeneration. This is a highly
rational and efficient regeneration mechanism, in which the damaged
muscle itself activates satellite cells for regeneration.

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