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Theodore Lowe, Ap #867-859
Sit Rd, Azusa New York

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Published Research

Published research in the medical literature from the Darrow Stem
Cell Institute

Treatment of shoulder osteoarthritis and rotator cuff
tears with bone marrow concentrate and whole bone marrow
injections

The Darrow Stem Cell Institute has published new research on the
treatment of shoulder osteoarthritis and rotator cuff tears with
bone marrow derived stem cells.The research appears in the
peer-reviewed journalCogent Medicine. The study can be found here
in its entirety: Treatment
of shoulder osteoarthritis and rotator cuff tears with bone marrow
concentrate and whole bone marrow injections
 with a
June 20, 2019 publication date.

Treatment of shoulder osteoarthritis and rotator cuff
tears with bone marrow concentrate and whole bone marrow
injections

Marc Darrow, Brent Shaw, Nicholas Schmidt, Gabrielle Boeger &
Saskia Budgett | Udo Schumacher (Reviewing editor)
Article: 1628883 | Received 02 Jan 2019, Accepted 30 May 2019,
Accepted author version posted online: 18 Jun 2019, Published
online: 20 Jun 2019

Short-Term Outcomes in Treatment of Knee Osteoarthritis
with Four Bone Marrow Concentrate Injections

Citation: Short-Term Outcomes in Treatment of Knee
Osteoarthritis With 4 Bone Marrow Concentrate Injections
Brent Shaw, Marc Darrow, MD JD : Darrow Stem Cell Institute, Los
Angeles, CA, USA
Armen Derian : Mayo Clinic, Phoenix, AZ, USA
Clinical Medicine Insights: Arthritis and Musculoskeletal
Disorders
 June 18, 2018 Link to study http://journals.sagepub.com/doi/10.1177/1179544118781080

BACKGROUND.

Preliminary research suggests that bone marrow concentrate
(BMC), which contains mesenchymal stem cells and platelets, is a
promising treatment for knee osteoarthritis. The aim of this study
was to build upon this preliminary research by reporting the
short-term progress of fifteen patients (twenty knees) with knee
osteoarthritis through four BMC treatments.

METHODS

Patients were advised to receive BMC injections approximately
two weeks apart. The last follow-up was conducted a mean 86 days
after the first treatment. Baseline and post-treatment outcomes of
resting pain, active pain, lower functionality scale, and overall
improvement percentage were compared after each treatment.

RESULTS

On average, patients experienced a 2.1 decrease in resting pain,
a 3.5 decrease in active pain, and a 9.8 increase in functionality
score at the final follow-up. Additionally, patients reported a
mean 67% total overall improvement at study conclusion. Outcomes at
the final follow-up after the fourth treatment were statistically
significant compared to outcomes at baseline, after first
treatment, after second treatment, and after third treatment.

CONCLUSIONS

These results are promising, and additional research with a
larger sample size and longer follow up is needed to further
examine the treatment effectiveness of multiple BMC injections for
knee osteoarthritis.

 

Short-Term Outcomes in Treatment of Hip Osteoarthritis
with Four Bone Marrow Concentrate Injections: A Case
Series

Darrow M, Shaw B, Darrow B, Wisz S. Short-Term Outcomes of
Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate
Injections: A Case Series. Clinical Medicine Insights: Case
Reports. 2018 Aug;11:1179547618791574. http://journals.sagepub.com/doi/full/10.1177/1179547618791574

ABSTRACT

The use of mesenchymal stem cells from bone marrow concentrate
(BMC) has become an increasingly popular option as an alternative
to total joint replacement. Although there is evidence to support
the use of BMC injections to improve quality of life for patients
with knee osteoarthritis (OA), there is limited evidence to support
its use in patients with hip OA. This case series provides the
short-term outcomes of four patients who each underwent four BMC
injections. On average, the last follow up was administered three
and half months after the first injection. The results show that
patients experienced decreased resting and active pain compared to
baseline and mean 72.4% total overall improvement. Patients also
reported less difficulty in performing daily activities following
the procedure. These encouraging results warrant further research
to better understand the effects of BMC injections on hip OA.

Preliminary Results: The table below illustrates the
baseline and post-treatment outcomes of four osteoarthritic hips
that underwent four stem cell treatments

Treatment of Lower Back Pain with Bone Marrow
Concentrate

https://biomedres.us/pdfs/BJSTR.MS.ID.001461.pdf

Abstract:

Lower back pain can be a debilitating condition that is often
caused by ligament and fascial sprains, and muscle strains. Even
though the diagnosis may be a herniated disc, facet arthropathy,
degenerative disc disease, spinal stenosis, scoliosis, spondylosis,
spondylolisthesis, or other pathology, we have found for the past
twenty years, with thousands of successfully treated patients, that
the actual pain generator may not even be noted in the diagnosis.
With the risk of adverse complications of surgery and
ineffectiveness of epidural injections, bone marrow concentrate
(BMC) offers a promising treatment to treat lower back pain. BMC
contains mesenchymal stem cells that have the ability to
differentiate into muscle, cartilage, and bone, in addition to
releasing trophic factors that enhance tissue regeneration. The
four patients included in this study underwent at least one BMC
injection to the entheses of muscles, fascia, and ligaments
surrounding the lumbar spine. At one-year follow-up all four
patients experienced a decrease in resting and active pain.
Patients also reported a mean 80% total overall improvement and
were able to perform daily activities with less difficulty. These
encouraging results warrant further investigation of the full
potential of BMC injections for lower back pain.

Preliminary Data: The table below illustrates the
baseline and post-treatment outcomes of four lower back pain
patients that underwent stem cell procedures

PLATELET RICH PLASMA THERAPY ON UNRESOLVED CHRONIC WRIST PAIN

Orthopedic & Muscular System: Current Research (March
2019).

The objective of our study, was to share with the medical
community our observations on pain and function in 6 patients who
had their wrists (one patient had both wrists treated), who
underwent PRP injections to the ligaments and joints of the wrist.
We hypothesize that by strengthening the ligaments and regrowing
tissue within the wrist joints, we may provide patients improved
quality of life and pain relief.


You can download the entire study

These findings have been summarized here:

  • Platelet-Rich Plasma (PRP) is a minimally invasive surgical
    alternative that uses components from a patient’s own blood to
    regrow tissue and relieve pain. This study investigated the
    clinical effect of PRP on unresolved wrist pain.
  • Six patients and seven wrists underwent a series of two to four
    PRP injections for unresolved wrist pain.
  • Outcomes of resting pain, active pain, upper
    functionality scale, and overall improvement percentage were
    measured and compared to baseline.
  • The final follow-up was performed an average of 6.57 months
    after injection.
  • All patients included in the study experienced decreases in
    pain and improvement in functionality score at final
    follow-up.

STUDIES SUBMITTED FOR PUBLICATION SECTION

Treatment of Unresolved Lower Back Pain with
Platelet-Rich Plasma Injections

Background: Platelet-Rich Plasma (PRP) is a non-invasive
modality that has been used to treat musculoskeletal conditions for
the past two decades. Based on our research, there were no
publications that studied the effect of PRP on unresloved lower
back pain. The aim of this study was to report the clinical
outcomes of patients who received PRP injections to treat
unresolved lower back pain.

Methods: 67 patients underwent a series one, two, or three PRP
injections into the ligaments, muscle, and fascia surrounding the
lumbar spine. Patients who received two treatments received
injections a mean 24 days apart and patients who received three
treatments received injections a mean 20.50 days apart. Baseline
and posttreatment outcomes of resting pain, active pain, lower
functionality scale, and overall improvement percentage were
compared to baseline and between groups.

Results: Patients who received one PRP injection reported 36.33%
overall improvement and experienced significant improvements in
active pain relief. These same patients experienced improvements in
resting pain and functionality score, yet these results were not
statistically significant. Patients who received a series of two
and three treatments experienced significant decreases in resting
pain and active pain and reported 46.17% and 54.91% total overall
improvement respectively. In addition, they were able to perform
daily activities with less difficulty than prior to treatment.

Conclusions:

These results demonstrate that PRP injections may be a viable
conservative approach to treat lower back pain. Additional research
is needed to confirm these findings.

Studies Awaiting Publication

1. Comparing Outcomes of Spun and Whole Bone Marrow Concentrate
injections in Hip and Shoulder Pain Patients

2. Treatment of Chronic Low Back Pain with Platelet-Rich Plasma
Injections

3. Treatment of Hand and Wrist Osteoarthritis with Bone Marrow
Concentrate: A Case Series

4. Treatment of Ankle Osteoarthritis with Bone Marrow
Concentrate Injections

5. Treatment of Chronic Knee Pain with Platelet-Rich Plasma
Injections

6. Treatment of Chronic Hip Pain with Platelet-Rich Plasma
Injections.

Do you have questions? Ask Dr. Darrow

Please enable JavaScript in your browser to complete this
form.

Name *

First
Last
Email *
Phone Number *
Comment or Message *
Submit

 


A leading provider of
stem cell therapy, platelet rich plasma and prolotherapy
11645 WILSHIRE BOULEVARD SUITE 120, LOS ANGELES, CA 90025

PHONE: (800)
300-9300
or 310-231-7000

Stem cell and PRP injections for musculoskeletal conditions are
not FDA approved. We do not treat disease. We do not offer IV
treatments. There are no guarantees that this treatment will help
you. Prior to our treatment, seek advice from your medical
physician. Neither Dr. Darrow, nor any associate, offer medical
advice from this transmission. This information is offered for
educational purposes only. The transmission of this information
does not create a physician-patient relationship between you and
Dr. Darrow or any associate. We do not guarantee the accuracy,
completeness, usefulness or adequacy of any resource, information,
product, or process available from this transmission. We cannot be
responsible for the receipt of your email since spam filters and
servers often block their receipt. If you have a medical issue,
please call our office. If you have a medical emergency, please
call 911.

Published research in the medical literature from the Darrow Stem
Cell Institute

Treatment of shoulder osteoarthritis and rotator cuff
tears with bone marrow concentrate and whole bone marrow
injections

The Darrow Stem Cell Institute has published new research on the
treatment of shoulder osteoarthritis and rotator cuff tears with
bone marrow derived stem cells.The research appears in the
peer-reviewed journalCogent Medicine. The study can be found here
in its entirety: Treatment
of shoulder osteoarthritis and rotator cuff tears with bone marrow
concentrate and whole bone marrow injections
 with a
June 20, 2019 publication date.

Treatment of shoulder osteoarthritis and rotator cuff
tears with bone marrow concentrate and whole bone marrow
injections

Marc Darrow, Brent Shaw, Nicholas Schmidt, Gabrielle Boeger &
Saskia Budgett | Udo Schumacher (Reviewing editor)
Article: 1628883 | Received 02 Jan 2019, Accepted 30 May 2019,
Accepted author version posted online: 18 Jun 2019, Published
online: 20 Jun 2019

Short-Term Outcomes in Treatment of Knee Osteoarthritis
with Four Bone Marrow Concentrate Injections

Citation: Short-Term Outcomes in Treatment of Knee
Osteoarthritis With 4 Bone Marrow Concentrate Injections
Brent Shaw, Marc Darrow, MD JD : Darrow Stem Cell Institute, Los
Angeles, CA, USA
Armen Derian : Mayo Clinic, Phoenix, AZ, USA
Clinical Medicine Insights: Arthritis and Musculoskeletal
Disorders
 June 18, 2018 Link to study http://journals.sagepub.com/doi/10.1177/1179544118781080

BACKGROUND.

Preliminary research suggests that bone marrow concentrate
(BMC), which contains mesenchymal stem cells and platelets, is a
promising treatment for knee osteoarthritis. The aim of this study
was to build upon this preliminary research by reporting the
short-term progress of fifteen patients (twenty knees) with knee
osteoarthritis through four BMC treatments.

METHODS

Patients were advised to receive BMC injections approximately
two weeks apart. The last follow-up was conducted a mean 86 days
after the first treatment. Baseline and post-treatment outcomes of
resting pain, active pain, lower functionality scale, and overall
improvement percentage were compared after each treatment.

RESULTS

On average, patients experienced a 2.1 decrease in resting pain,
a 3.5 decrease in active pain, and a 9.8 increase in functionality
score at the final follow-up. Additionally, patients reported a
mean 67% total overall improvement at study conclusion. Outcomes at
the final follow-up after the fourth treatment were statistically
significant compared to outcomes at baseline, after first
treatment, after second treatment, and after third treatment.

CONCLUSIONS

These results are promising, and additional research with a
larger sample size and longer follow up is needed to further
examine the treatment effectiveness of multiple BMC injections for
knee osteoarthritis.

 

Short-Term Outcomes in Treatment of Hip Osteoarthritis
with Four Bone Marrow Concentrate Injections: A Case
Series

Darrow M, Shaw B, Darrow B, Wisz S. Short-Term Outcomes of
Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate
Injections: A Case Series. Clinical Medicine Insights: Case
Reports. 2018 Aug;11:1179547618791574. http://journals.sagepub.com/doi/full/10.1177/1179547618791574

ABSTRACT

The use of mesenchymal stem cells from bone marrow concentrate
(BMC) has become an increasingly popular option as an alternative
to total joint replacement. Although there is evidence to support
the use of BMC injections to improve quality of life for patients
with knee osteoarthritis (OA), there is limited evidence to support
its use in patients with hip OA. This case series provides the
short-term outcomes of four patients who each underwent four BMC
injections. On average, the last follow up was administered three
and half months after the first injection. The results show that
patients experienced decreased resting and active pain compared to
baseline and mean 72.4% total overall improvement. Patients also
reported less difficulty in performing daily activities following
the procedure. These encouraging results warrant further research
to better understand the effects of BMC injections on hip OA.

Preliminary Results: The table below illustrates the
baseline and post-treatment outcomes of four osteoarthritic hips
that underwent four stem cell treatments

Treatment of Lower Back Pain with Bone Marrow
Concentrate

https://biomedres.us/pdfs/BJSTR.MS.ID.001461.pdf

Abstract:

Lower back pain can be a debilitating condition that is often
caused by ligament and fascial sprains, and muscle strains. Even
though the diagnosis may be a herniated disc, facet arthropathy,
degenerative disc disease, spinal stenosis, scoliosis, spondylosis,
spondylolisthesis, or other pathology, we have found for the past
twenty years, with thousands of successfully treated patients, that
the actual pain generator may not even be noted in the diagnosis.
With the risk of adverse complications of surgery and
ineffectiveness of epidural injections, bone marrow concentrate
(BMC) offers a promising treatment to treat lower back pain. BMC
contains mesenchymal stem cells that have the ability to
differentiate into muscle, cartilage, and bone, in addition to
releasing trophic factors that enhance tissue regeneration. The
four patients included in this study underwent at least one BMC
injection to the entheses of muscles, fascia, and ligaments
surrounding the lumbar spine. At one-year follow-up all four
patients experienced a decrease in resting and active pain.
Patients also reported a mean 80% total overall improvement and
were able to perform daily activities with less difficulty. These
encouraging results warrant further investigation of the full
potential of BMC injections for lower back pain.

Preliminary Data: The table below illustrates the
baseline and post-treatment outcomes of four lower back pain
patients that underwent stem cell procedures

PLATELET RICH PLASMA THERAPY ON UNRESOLVED CHRONIC WRIST PAIN

Orthopedic & Muscular System: Current Research (March
2019).

The objective of our study, was to share with the medical
community our observations on pain and function in 6 patients who
had their wrists (one patient had both wrists treated), who
underwent PRP injections to the ligaments and joints of the wrist.
We hypothesize that by strengthening the ligaments and regrowing
tissue within the wrist joints, we may provide patients improved
quality of life and pain relief.


You can download the entire study

These findings have been summarized here:

  • Platelet-Rich Plasma (PRP) is a minimally invasive surgical
    alternative that uses components from a patient’s own blood to
    regrow tissue and relieve pain. This study investigated the
    clinical effect of PRP on unresolved wrist pain.
  • Six patients and seven wrists underwent a series of two to four
    PRP injections for unresolved wrist pain.
  • Outcomes of resting pain, active pain, upper
    functionality scale, and overall improvement percentage were
    measured and compared to baseline.
  • The final follow-up was performed an average of 6.57 months
    after injection.
  • All patients included in the study experienced decreases in
    pain and improvement in functionality score at final
    follow-up.

STUDIES SUBMITTED FOR PUBLICATION SECTION

Treatment of Unresolved Lower Back Pain with
Platelet-Rich Plasma Injections

Background: Platelet-Rich Plasma (PRP) is a non-invasive
modality that has been used to treat musculoskeletal conditions for
the past two decades. Based on our research, there were no
publications that studied the effect of PRP on unresloved lower
back pain. The aim of this study was to report the clinical
outcomes of patients who received PRP injections to treat
unresolved lower back pain.

Methods: 67 patients underwent a series one, two, or three PRP
injections into the ligaments, muscle, and fascia surrounding the
lumbar spine. Patients who received two treatments received
injections a mean 24 days apart and patients who received three
treatments received injections a mean 20.50 days apart. Baseline
and posttreatment outcomes of resting pain, active pain, lower
functionality scale, and overall improvement percentage were
compared to baseline and between groups.

Results: Patients who received one PRP injection reported 36.33%
overall improvement and experienced significant improvements in
active pain relief. These same patients experienced improvements in
resting pain and functionality score, yet these results were not
statistically significant. Patients who received a series of two
and three treatments experienced significant decreases in resting
pain and active pain and reported 46.17% and 54.91% total overall
improvement respectively. In addition, they were able to perform
daily activities with less difficulty than prior to treatment.

Conclusions:

These results demonstrate that PRP injections may be a viable
conservative approach to treat lower back pain. Additional research
is needed to confirm these findings.

Studies Awaiting Publication

1. Comparing Outcomes of Spun and Whole Bone Marrow Concentrate
injections in Hip and Shoulder Pain Patients

2. Treatment of Chronic Low Back Pain with Platelet-Rich Plasma
Injections

3. Treatment of Hand and Wrist Osteoarthritis with Bone Marrow
Concentrate: A Case Series

4. Treatment of Ankle Osteoarthritis with Bone Marrow
Concentrate Injections

5. Treatment of Chronic Knee Pain with Platelet-Rich Plasma
Injections

6. Treatment of Chronic Hip Pain with Platelet-Rich Plasma
Injections.

Do you have questions? Ask Dr. Darrow

Please enable JavaScript in your browser to complete this
form.

Name *

First
Last
Email *
Phone Number *
Comment or Message *
Submit

 


A leading provider of
stem cell therapy, platelet rich plasma and prolotherapy
11645 WILSHIRE BOULEVARD SUITE 120, LOS ANGELES, CA 90025

PHONE: (800)
300-9300
or 310-231-7000

Stem cell and PRP injections for musculoskeletal conditions are
not FDA approved. We do not treat disease. We do not offer IV
treatments. There are no guarantees that this treatment will help
you. Prior to our treatment, seek advice from your medical
physician. Neither Dr. Darrow, nor any associate, offer medical
advice from this transmission. This information is offered for
educational purposes only. The transmission of this information
does not create a physician-patient relationship between you and
Dr. Darrow or any associate. We do not guarantee the accuracy,
completeness, usefulness or adequacy of any resource, information,
product, or process available from this transmission. We cannot be
responsible for the receipt of your email since spam filters and
servers often block their receipt. If you have a medical issue,
please call our office. If you have a medical emergency, please
call 911.

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